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Thermosensitive Hydrogel Containing Doxycycline Exerts Inhibitory Effects on Abdominal Aortic Aneurysm Induced By Pancreatic Elastase in Mice
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-08 , DOI: 10.1002/adhm.201700671 Maomao Yu 1 , Anjie Dong 2 , Cong Chen 1 , Shuxin Xu 2 , Yini Cao 1 , Shu Liu 1, 3 , Qiang Zhang 4 , Rong Qi 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-08 , DOI: 10.1002/adhm.201700671 Maomao Yu 1 , Anjie Dong 2 , Cong Chen 1 , Shuxin Xu 2 , Yini Cao 1 , Shu Liu 1, 3 , Qiang Zhang 4 , Rong Qi 1
Affiliation
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Doxycycline (DOX) is reported to exert therapeutic effects against abdominal aortic aneurysm (AAA), a severe degenerative disease. In this study, a DOX hydrogel formulation of DOX/PECTgel is studied, and its phase transition behavior and in vitro release profiles are explored. In addition, the anti‐AAA effects and bioavailability of DOX/PECTgel are evaluated in an elastase induced AAA mouse model. The results show that the phase transition temperature of 30% poly(e‐caprolactone‐co‐1,4,8‐trioxa[4.6]spiro‐9‐undecanone) (PECT) solution is above 34 °C. In vitro release profiles of DOX/PECTgel indicate a fast release of DOX at the first two days, followed by a slow and sustained release for 14 d. In vivo single‐dose single subcutaneous injection of DOX/PECTgel containing 8.4 or 4.2 mg mL−1 DOX presents comparatively preventive effects on AAA, compared to intraperitoneal injections of DOX alone at a dose of 15 mg kg−1 for seven injections, while DOX bioavailability of the DOX/PECTgel treated groups is 1.39 times or 1.19 times of the DOX alone treated group, respectively.
中文翻译：
含强力霉素的热敏水凝胶对胰腺弹性蛋白酶诱导的小鼠腹主动脉瘤具有抑制作用。
据报道，强力霉素（DOX）对严重的退化性疾病腹主动脉瘤（AAA）发挥治疗作用。在这项研究中，研究了DOX / PECT凝胶的DOX水凝胶配方，并探讨了其相变行为和体外释放曲线。此外，在弹性蛋白酶诱导的AAA小鼠模型中评估了DOX / PECT凝胶的抗AAA效应和生物利用度。结果表明，30％的聚（ε-己内酯-co-1,4,8-三恶英[4.6] spiro-9-十一烷酮）（PECT）（PECT）溶液的相变温度高于34°C。DOX / PECT凝胶的体外释放曲线表明在头两天DOX快速释放，然后缓慢持续释放14天。体内单剂量单次皮下注射DOX / PECT与腹腔注射DOX剂量为15 mg kg -1的七次注射腹膜内注射相比，含有8.4或4.2 mg mL -1 DOX的凝胶对AAA具有相对的预防作用，而经DOX / PECT凝胶处理的组的DOX生物利用度为1.39单独使用DOX治疗组的1倍或1.19倍。
更新日期：2017-09-08
中文翻译：
含强力霉素的热敏水凝胶对胰腺弹性蛋白酶诱导的小鼠腹主动脉瘤具有抑制作用。
据报道，强力霉素（DOX）对严重的退化性疾病腹主动脉瘤（AAA）发挥治疗作用。在这项研究中，研究了DOX / PECT凝胶的DOX水凝胶配方，并探讨了其相变行为和体外释放曲线。此外，在弹性蛋白酶诱导的AAA小鼠模型中评估了DOX / PECT凝胶的抗AAA效应和生物利用度。结果表明，30％的聚（ε-己内酯-co-1,4,8-三恶英[4.6] spiro-9-十一烷酮）（PECT）（PECT）溶液的相变温度高于34°C。DOX / PECT凝胶的体外释放曲线表明在头两天DOX快速释放，然后缓慢持续释放14天。体内单剂量单次皮下注射DOX / PECT与腹腔注射DOX剂量为15 mg kg -1的七次注射腹膜内注射相比，含有8.4或4.2 mg mL -1 DOX的凝胶对AAA具有相对的预防作用，而经DOX / PECT凝胶处理的组的DOX生物利用度为1.39单独使用DOX治疗组的1倍或1.19倍。
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