Base-Mediated Synthesis of Unsymmetrical 1,3,5-Triazin-2-amines via Three-Component Reaction of Imidates, Guanidines, and Amides or Aldehydes,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Base-Mediated Synthesis of Unsymmetrical 1,3,5-Triazin-2-amines via Three-Component Reaction of Imidates, Guanidines, and Amides or Aldehydes
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-09-08 00:00:00 , DOI: 10.1021/acs.joc.7b01510
Liyang Pan ₁ , Zhenxing Li ₂ , Tao Ding ₁ , Xiaomin Fang ₁ , Wenkai Zhang ₁ , Hao Xu _{1,

2} , Yuanqing Xu ₁

Affiliation

A simple and efficient method for the base-mediated synthesis of unsymmetrical 1,3,5-triazin-2-amines has been developed. The protocol uses readily available imidates, guanidines, and amides or aldehydes as the starting materials, cesium carbonate as the base, no catalyst or additive is required, and the three-component reaction provides diverse 1,3,5-triazin-2-amines in moderate to good yields with tolerance of wide functional groups.

中文翻译：

碱介导的亚氨酸盐，胍盐和酰胺或醛的三组分反应合成不对称的1,3,5-三嗪-2-胺

已开发出一种简单有效的方法，用于碱介导的不对称1,3,5-triazin-2-amines的合成。该方案使用容易获得的酰亚胺化物，胍和酰胺或醛作为起始原料，碳酸铯作为碱，不需要催化剂或添加剂，三组分反应可提供多种1,3,5-三嗪-2-胺具有中等到良好的产量，对宽泛的官能团具有耐受性。

更新日期：2017-09-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文