The development of nonfouling zwitterionic materials has a wide range of biomedical and engineering applications. This work delineates the design and synthesis of a new zwitterionic material based on a naturally occurring compatible solute, ectoine, which is known to possess additional protective properties that stabilize even whole cells against ultraviolet radiation or cytotoxins. These properties and applications of ectoine inspire us to design a functional monomer containing the natural zwitterion moiety of ectoine imparting nonfouling properties and the methacrylate moiety for polymerization. The synthesis route designed for the ectoine methacrylate monomer is simple with a high yield, which is characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. After monomer synthesis, we have prepared a poly(ectoine) hydrogel via thermal polymerization. The equilibrium water content, degree of cross-linking, mechanical strength, and nonfouling properties are determined for polyectoine hydrogels with different cross-linking conditions. Poly(ectoine) hydrogels are shown to have highly hydrated and excellent nonfouling properties and can be considered to be a promising biomaterial.

中文翻译：

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聚（果胶）水凝胶可抵抗非特异性蛋白质吸附

非污染两性离子材料的开发具有广泛的生物医学和工程应用。这项工作描述了基于自然存在的相容性溶质ectoine的新型两性离子材料的设计和合成，已知该溶质具有额外的保护特性，甚至可以稳定整个细胞免受紫外线或细胞毒素的侵害。ectoine的这些特性和应用启发我们设计出一种功能单体，其中包含能够赋予其无污垢特性的ectoine的天然两性离子部分和用于聚合的甲基丙烯酸酯部分。设计用于甲基丙烯酸外皮素单体的合成路线简单，收率高，其特征在于核磁共振波谱法和质谱法。单体合成后，我们已经通过热聚合反应制备了聚（水杨素）水凝胶。确定了具有不同交联条件的聚ectoine水凝胶的平衡水含量，交联度，机械强度和防污性能。聚（水杨酸）水凝胶被证明具有高度水合和优异的防污性能，可以被认为是一种有前途的生物材料。