Metal-Free Nitration of the C(sp3)−H Bonds of 2-Oxindoles through Radical Coupling Reaction at Room Temperature,Advanced Synthesis & Catalysis

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Metal-Free Nitration of the C(sp3)−H Bonds of 2-Oxindoles through Radical Coupling Reaction at Room Temperature
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2017-09-08 03:05:51 , DOI: 10.1002/adsc.201700870
Wen-Ting Wei ₁ , Wen-Ming Zhu ₁ , Wei-Wei Ying ₁ , Yi-Ning Wang ₁ , Wen-Hui Bao ₁ , Le-Han Gao ₁ , Yun-Jie Luo ₁ , Hongze Liang ₁

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A metal-free nitration of the C(sp³)−H bonds of 2-oxindoles with t-BuONO through radical coupling reaction at room temperature has been developed. Using t-BuONO both as a nitrating reagent and as an oxidant, to couple with the C(sp³)−H bonds of 2-oxindoles, thus forming a new C−N bond without using any other reagents. This reaction provides a green and straightforward approach to some useful 3-nitro-2-oxindoles in moderate to good yields.

中文翻译：

通过室温下的自由基偶联反应对2-Oxindoles的C（sp3）-H键进行无金属硝化

通过室温下的自由基偶联反应，研究了2-氧吲哚与t - BuONO的C（sp ³）-H键的无金属硝化反应。同时使用t- BuONO作为硝化试剂和氧化剂与2-oxindoles的C（sp ³）-H键偶联，从而在不使用任何其他试剂的情况下形成新的C-N键。该反应以中等至良好的产率为某些有用的3-硝基-2-氧吲哚提供了一种绿色简便的方法。

更新日期：2017-09-08

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