Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence,ChemBioChem

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Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence
ChemBioChem ( IF 2.6 ) Pub Date : 2017-09-08 06:17:46 , DOI: 10.1002/cbic.201700390
Laurie Lannes ₁ , Phoebe Young ₂ , Christian Richter ₁ , Nina Morgner ₂ , Harald Schwalbe ₁

Affiliation

Preferred motif: The promoter of the BCL2 oncogene presents a C-rich sequence able to adopt i-motif or hairpin conformations in a pH-dependent manner. Herein, NMR spectroscopy is used to show that the RRM1 and RRM2 domains of the hnRNP LL protein cooperatively bind to CTCCC DNA elements, regardless of DNA conformation. In addition, the binding site can be mapped on the protein.

中文翻译：

hnRNP LL的N端串联域与BCL2启动子i-Motif DNA序列的相互作用

优选的基序：BCL2癌基因的启动子呈现出富含C的序列，该序列能够以pH依赖性方式采用i-基序或发夹构象。本文中，NMR光谱用于显示hnRNP LL蛋白的RRM1和RRM2结构域与CTCCC DNA元素协同结合，而与DNA构象无关。另外，结合位点可以定位在蛋白质上。

更新日期：2017-09-08

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