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Recent Advances in Organocatalytic Glycosylations
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-08 , DOI: 10.1002/ejoc.201700785 Ryan Williams 1 , M. Carmen Galan 1
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-08 , DOI: 10.1002/ejoc.201700785 Ryan Williams 1 , M. Carmen Galan 1
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Carbohydrates play a pivotal role in biological systems and present an opportunity to develop potent carbohydrate-derived therapeutics and diagnostic tools for the treatment and detection of disease. To better comprehend the biological functions of carbohydrates, access to pure and structurally defined oligosaccharides is needed. Oligosaccharides are commonly synthesized by chemical means; however, despite progress in glycosylation chemistry, the efficient and stereoselective formation of glycosidic bonds by mild, nontoxic and low-cost methods remains a challenge. Organocatalysis is an exciting field that utilizes small organic molecules to effect chemical transformation where traditionally transition metal catalysis would be required. This microreview presents recent advances in the application of organocatalysis to carbohydrate chemistry and in particular to the stereoselective synthesis of oligosaccharides.
中文翻译：
有机催化糖基化的最新进展
碳水化合物在生物系统中发挥着关键作用，并为开发用于治疗和检测疾病的有效碳水化合物衍生疗法和诊断工具提供了机会。为了更好地理解碳水化合物的生物学功能，需要获得纯的和结构明确的寡糖。寡糖通常通过化学方法合成；然而，尽管糖基化化学取得了进展，但通过温和、无毒和低成本的方法有效和立体选择性地形成糖苷键仍然是一个挑战。有机催化是一个令人兴奋的领域，它利用有机小分子来实现传统过渡金属催化所需的化学转化。
更新日期：2017-09-08
中文翻译：
有机催化糖基化的最新进展
碳水化合物在生物系统中发挥着关键作用，并为开发用于治疗和检测疾病的有效碳水化合物衍生疗法和诊断工具提供了机会。为了更好地理解碳水化合物的生物学功能，需要获得纯的和结构明确的寡糖。寡糖通常通过化学方法合成；然而，尽管糖基化化学取得了进展，但通过温和、无毒和低成本的方法有效和立体选择性地形成糖苷键仍然是一个挑战。有机催化是一个令人兴奋的领域，它利用有机小分子来实现传统过渡金属催化所需的化学转化。
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