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Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes.
Cell Metabolism ( IF 27.7 ) Pub Date : 2018-Jan-09 , DOI: 10.1016/j.cmet.2017.08.007
Cristina Aguayo-Mazzucato 1 , Susan Bonner-Weir 1
Affiliation  

Diabetes is the result of having inadequate supply of functional insulin-producing β cells. Two possible approaches for replenishing the β cells are: (1) replacement by transplanting cadaveric islets or β cells derived from human embryonic stem cells/induced pluripotent stem cells and (2) induction of endogenous regeneration. This review focuses on endogenous regeneration, which can follow two pathways: enhanced replication of existing β cells and formation of new β cells from cells not expressing insulin, either by conversion from a differentiated cell type (transdifferentiation) or differentiation from progenitors (neogenesis). Exciting progress on both pathways suggest that regeneration may have therapeutic promise.

中文翻译:

胰腺β细胞再生可作为糖尿病的一种治疗方法。

糖尿病是功能性产生胰岛素的β细胞供应不足的结果。补充β细胞的两种可能方法是:(1)通过移植来自人胚胎干细胞/诱导的多能干细胞的尸体胰岛或β细胞进行置换,以及(2)诱导内源性再生。这篇综述着重于内源性再生,它可以通过两种途径进行:通过分化细胞类型的转化(转分化)或祖细胞分化(新生),增强现有β细胞的复制和从不表达胰岛素的细胞中形成新的β细胞。两种途径均取得令人兴奋的进展,表明再生可能具有治疗前景。
更新日期:2017-09-07
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