Several human papillomavirus type 16 (HPV16) oncoproteins contribute to cellular transformation in vitro. In this issue of Cell, Mirabello and colleagues use high-throughput sequencing data to assess the diversity of HPV16 isolates from human patients. These data suggest that the E7 oncoprotein is the fundamental contributor to in vivo carcinogenesis.

中文翻译：

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人群控制：E7保守是癌症的关键。

几种人乳头瘤病毒16型（HPV16）癌蛋白有助于体外细胞转化。在本期《细胞》杂志中，Mirabello及其同事使用高通量测序数据评估了人类患者中HPV16分离株的多样性。这些数据表明，E7癌蛋白是体内致癌作用的根本原因。