The ability to control drug loading and release is the most important feature in the development of medical devices. In this research, we prepared a functional nanocoating technology to incorporate a drug-release layer onto a desired substrate. The multilayer films were prepared using chitosan (CHI) and carboxymethyl cellulose (CMC) polysaccharides by the layer-by-layer (LbL) method. By using chemical cross-linking to change the inner structure of the assembled multilayer, we could control the extent of drug loading and release. The cross-linked multilayer film had a porous structure and enhanced water wettability. Interestingly, more of the small-molecule drug was loaded into and released from the non-cross-linked multilayer film, whereas more of the macromolecular drug was loaded into and released from the cross-linked multilayer film. These results indicate that drug loading and release can be easily controlled according to the molecular weight of the desired drug by changing the structure of the film.

中文翻译：

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取决于壳聚糖/纤维素多层纳米膜诱导孔隙率的药物加载和释放行为

控制药物加载和释放的能力是医疗设备开发中最重要的功能。在这项研究中，我们准备了一种功能性纳米涂层技术，将药物释放层结合到所需的基材上。使用壳聚糖（CHI）和羧甲基纤维素（CMC）多糖，通过逐层（LbL）方法制备多层膜。通过使用化学交联改变组装的多层的内部结构，我们可以控制药物的上载和释放程度。交联的多层膜具有多孔结构并提高了水润湿性。有趣的是，更多的小分子药物被装载到非交联的多层膜中并从中释放，而更多的大分子药物被装载到交联的多层膜中并从中释放。