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Application of bis-2-(trimethylsilyl)ethyl diselenide to the synthesis of selenium-containing amino acid derivatives
Tetrahedron ( IF 2.1 ) Pub Date : 2017-09-07 , DOI: 10.1016/j.tet.2017.09.004 Tsubasa Yonezawa , Masahito Yamaguchi , Masayuki Ninomiya , Mamoru Koketsu
中文翻译:
双-2-(三甲基甲硅烷基)乙基二硒化物在合成含硒氨基酸衍生物中的应用
更新日期:2017-09-07
Tetrahedron ( IF 2.1 ) Pub Date : 2017-09-07 , DOI: 10.1016/j.tet.2017.09.004 Tsubasa Yonezawa , Masahito Yamaguchi , Masayuki Ninomiya , Mamoru Koketsu
Selenium-containing amino acids play a pivotal role as biomaterials for the synthesis of Se-dependent enzymes and repair proteins. Especially, selenocysteine and selenoglutathione are prominently involved in fundamental biological processes. In this study, a series of selenocysteine (Sec) and selenoglutathione (GSeH) derivatives were synthesized via 2-(trimethylsilyl)ethylselenation as a key step. Our findings suggested the relevance and application of a 2-(trimethylsilyl)ethylselenyl group to the Se-containing amino acid synthesis.
中文翻译:
双-2-(三甲基甲硅烷基)乙基二硒化物在合成含硒氨基酸衍生物中的应用
含硒氨基酸作为生物材料,对硒依赖性酶和修复蛋白的合成起着举足轻重的作用。特别地,硒代半胱氨酸和硒代谷胱甘肽主要参与基本的生物学过程。在这项研究中,一系列的硒代半胱氨酸(Sec)和硒代谷胱甘肽(GSeH)衍生物是通过2-(三甲基甲硅烷基)乙基硒化合成的关键步骤。我们的发现表明2-(三甲基甲硅烷基)乙基硒基与含硒氨基酸合成的相关性和应用。