A new hybrid nanogel system using polypetide-engineered coated gold nanorods has been developed for targeted drug delivery and tumor chemo-photothermal therapy. A triblock engineered polypeptide PC₁₀A(RGD) was immobilized on the surface of gold nanorods by the electrostatic adsorption. The immobilized PC₁₀A(RGD) formed hydrogel by self-assembly to load doxorubicin for chemotherapy. Coating polypeptide-engineering hydrogel on gold nanorods enhanced the stability in high-salt media and significantly reduced the cytotoxicity. An arginine-glycine-aspartic acid motif was introduced into the polypeptide on the surface of hybrid nanogels to promote cellular uptake through receptor-mediated endocytosis in α_vβ₃ overexpressing HeLa cells. In addition, compared with single chemotherapy and near-infrared photothermal therapy, the combination therapy has a synergistic effect on the cancer cells. Thus, the chemo-photothermal therapy based on polypeptide-engineered hydrogel coated gold nanorods and doxorubicin is expected to have great potential impact on cancer therapy.

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多肽工程水凝胶包被的金纳米棒用于靶向药物递送和化学光热疗法

已经开发出了一种新的杂化纳米凝胶系统，该系统使用了多肽工程技术制成的涂层金纳米棒，用于靶向药物递送和肿瘤化学光热疗法。通过静电吸附将三嵌段改造的多肽PC ₁₀ A（RGD）固定在金纳米棒的表面上。固定的PC ₁₀ A（RGD）通过自组装形成水凝胶，以加载阿霉素进行化疗。在金纳米棒上涂覆多肽工程水凝胶增强了在高盐介质中的稳定性，并显着降低了细胞毒性。精氨酸-甘氨酸-天冬氨酸基序引入到混合纳米凝胶的表面上的多肽，以促进通过受体介导的内吞作用的细胞摄取在α _v β ₃过度表达HeLa细胞。另外，与单一化学疗法和近红外光热疗法相比，联合疗法对癌细胞具有协同作用。因此，基于多肽工程水凝胶包被的金纳米棒和阿霉素的化学光热疗法有望对癌症治疗产生巨大的潜在影响。