Despite significant progress in developing new drugs for seizure control, epilepsy still affects 1% of the global population and is drug-resistant in more than 30% of cases. To improve the therapeutic efficacy of epilepsy medication, a promising approach is to deliver anti-epilepsy drugs directly to affected brain areas using local drug delivery systems. The drug delivery systems must meet a number of criteria, including high drug loading efficiency, biodegradability, neuro-cytocompatibility and predictable drug release profiles. Here we report the development of fibre- and sphere-based microcapsules that exhibit controllable uniform morphologies and drug release profiles as predicted by mathematical modelling. Importantly, both forms of fabricated microcapsules are compatible with human brain derived neural stem cells and their differentiation to neurons and supporting neuroglia, indicating clinical compliance for neural transplantation and therapeutic drug delivery.

中文翻译：

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用于治疗癫痫的载药聚合物微胶囊的开发

尽管在开发用于控制癫痫发作的新药方面取得了重大进展，但癫痫病仍影响着全球1％的人口，并且在超过30％的病例中具有耐药性。为了提高癫痫药物的治疗效果，一种有前途的方法是使用局部药物递送系统将抗癫痫药直接递送至受影响的大脑区域。药物输送系统必须满足许多标准，包括高药物装载效率，生物降解性，神经细胞相容性和可预测的药物释放曲线。在这里，我们报告了基于纤维和球形的微囊的发展，这些微囊表现出可控的均匀形态和药物释放曲线，正如数学建模所预测的那样。重要的，