Let enzymes do the work: Semirational engineering is applied successfully to accelerate the laboratory evolution of Pseudomonas putida nitrilase for the biosynthesis of nicotinic acid. The mutant nitrilases display a significant improvement in catalytic efficiency for the synthesis of nicotinic acid compared with the wild type.

中文翻译：

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半理性工程加快了硝化酶催化烟酸生物合成效率的实验室发展

让酶发挥作用：成功应用半定量工程技术加快了恶臭假单胞菌腈水解酶用于烟酸生物合成的实验室发展。与野生型相比，突变型腈水解酶显示出烟酸合成催化效率的显着提高。