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Development of Graphene Oxide-/Galactitol Polyester-Based Biodegradable Composites for Biomedical Applications
ACS Omega ( IF 3.7 ) Pub Date : 2017-09-07 00:00:00 , DOI: 10.1021/acsomega.7b01139 Janeni Natarajan 1 , Giridhar Madras 1 , Kaushik Chatterjee 1
ACS Omega ( IF 3.7 ) Pub Date : 2017-09-07 00:00:00 , DOI: 10.1021/acsomega.7b01139 Janeni Natarajan 1 , Giridhar Madras 1 , Kaushik Chatterjee 1
Affiliation
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We have developed nanocomposites based on galactitol/adipic acid in the molar ratio of 1:1 with different weight percentages of graphene oxide (GO). The objective of this study was to analyze the effect of enhanced physicochemical properties achieved due to the addition of GO to the polymers on cellular responses. The chemical structures of the polymer and composites were confirmed by Fourier transform infrared spectroscopy. Scanning electron microscopy revealed the uniform distribution of GO in the polymers. Differential scanning calorimetry showed no significant variation in the glass-transition temperature of the nanocomposites. Dynamic mechanical analysis demonstrated the increase of Young’s modulus with the increase in the addition of GO to the polymer from 0.5 to 1 wt % and a dramatic decrease in modulus with the addition of 2 wt % GO to the polyester. Contact angle analysis illustrated a slight increase in hydrophilicity with the addition of GO to the polyester. Investigations on the hydrolytic degradation and dye release were performed and revealed that the degradation and release decreased with the increase in the weight percentages of GO but increased for 2 wt % GO with the polymer. The rates of degradation and dye release followed first-order and Higuchi kinetics, respectively. The initial in vitro cytocompatibility studies exhibited minimal toxicity. Mineralization studies proved that these nanocomposites stimulated osteogenesis. This study has salient implications for designing biodegradable polymers for use as scaffolds with tailored release.
中文翻译：
开发用于生物医学应用的氧化石墨烯/半乳糖醇聚酯基可生物降解复合材料
我们开发了基于摩尔比为 1:1 的半乳糖醇/己二酸和不同重量百分比的氧化石墨烯 (GO) 的纳米复合材料。本研究的目的是分析由于向聚合物中添加 GO 而增强的物理化学特性对细胞反应的影响。通过傅里叶变换红外光谱证实了聚合物和复合材料的化学结构。扫描电子显微镜显示GO在聚合物中均匀分布。差示扫描量热法显示纳米复合材料的玻璃化转变温度没有显着变化。动态机械分析表明，随着聚合物中 GO 的添加量从 0.5 wt% 增加到 1 wt%，杨氏模量增加；而当聚酯中 GO 的添加量为 2 wt% 时，模量急剧下降。接触角分析表明，在聚酯中添加 GO 后，亲水性略有增加。对水解降解和染料释放进行了研究，结果表明，降解和释放随着 GO 重量百分比的增加而减少，但当 GO 与聚合物的重量百分比为 2 时，降解和释放则增加。降解速率和染料释放速率分别遵循一级动力学和 Higuchi 动力学。最初的体外细胞相容性研究显示出最小的毒性。矿化研究证明这些纳米复合材料可以刺激成骨。这项研究对于设计可生物降解的聚合物作为具有定制释放的支架具有显着的意义。
更新日期：2017-09-07
中文翻译：
开发用于生物医学应用的氧化石墨烯/半乳糖醇聚酯基可生物降解复合材料
我们开发了基于摩尔比为 1:1 的半乳糖醇/己二酸和不同重量百分比的氧化石墨烯 (GO) 的纳米复合材料。本研究的目的是分析由于向聚合物中添加 GO 而增强的物理化学特性对细胞反应的影响。通过傅里叶变换红外光谱证实了聚合物和复合材料的化学结构。扫描电子显微镜显示GO在聚合物中均匀分布。差示扫描量热法显示纳米复合材料的玻璃化转变温度没有显着变化。动态机械分析表明，随着聚合物中 GO 的添加量从 0.5 wt% 增加到 1 wt%，杨氏模量增加；而当聚酯中 GO 的添加量为 2 wt% 时，模量急剧下降。接触角分析表明，在聚酯中添加 GO 后，亲水性略有增加。对水解降解和染料释放进行了研究，结果表明，降解和释放随着 GO 重量百分比的增加而减少，但当 GO 与聚合物的重量百分比为 2 时，降解和释放则增加。降解速率和染料释放速率分别遵循一级动力学和 Higuchi 动力学。最初的体外细胞相容性研究显示出最小的毒性。矿化研究证明这些纳米复合材料可以刺激成骨。这项研究对于设计可生物降解的聚合物作为具有定制释放的支架具有显着的意义。
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