Models of ΛΛ-4⁴⁺, Λ-3²⁺, and Λ-2²⁺ (top bound) and ΔΔ-4⁴⁺, Δ-3²⁺, and Δ-2²⁺ (bottom bound) are shown in a complex with c-MYC 1-2-1 G-quadruplex forming oligonucleotide construct. The tatpp moiety in 4⁴⁺ or 3²⁺ is capable of DNA double strand scission in the hypoxic environment of tumor cells. Compounds 4⁴⁺ and 3²⁺ have shown activity against non-small lung cell tumors in mouse models.

中文翻译：

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配体结构对G-四链体DNA单和双钌多吡啶基配合物分子识别的热力学影响

的ΛΛ-模型4 ^{4 +}，Λ- 3 ²⁺，和Λ- 2 ²⁺（顶部结合的）和ΔΔ- 4 ^{4 +}，Δ- 3 ²⁺，和Δ- 2 ²⁺（底部结合）以示出与形成c-MYC 1-2-1 G-四链体的寡核苷酸构建体的复合体。在肿瘤细胞的低氧环境中，4 ⁴⁺或3 ^2+中的tatpp部分能够进行DNA双链断裂。在小鼠模型中，化合物4 ⁴⁺和3 ²⁺已显示出对非小肺细胞肿瘤的活性。