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Mannoside recognition and degradation by bacteria
Biological Reviews ( IF 11.0 ) Pub Date : 2016-12-20 , DOI: 10.1111/brv.12316
Simon Ladevèze 1 , Elisabeth Laville 1 , Jordane Despres 2 , Pascale Mosoni 2 , Gabrielle Potocki-Véronèse 1
Affiliation  

Mannosides constitute a vast group of glycans widely distributed in nature. Produced by almost all organisms, these carbohydrates are involved in numerous cellular processes, such as cell structuration, protein maturation and signalling, mediation of protein–protein interactions and cell recognition. The ubiquitous presence of mannosides in the environment means they are a reliable source of carbon and energy for bacteria, which have developed complex strategies to harvest them. This review focuses on the various mannosides that can be found in nature and details their structure. It underlines their involvement in cellular interactions and finally describes the latest discoveries regarding the catalytic machinery and metabolic pathways that bacteria have developed to metabolize them.

中文翻译:

细菌对甘露糖苷的识别和降解

甘露糖苷构成了自然界中广泛分布的一大类聚糖。这些碳水化合物几乎由所有生物产生,参与许多细胞过程,例如细胞结构、蛋白质成熟和信号传导、蛋白质-蛋白质相互作用的介导和细胞识别。甘露糖苷在环境中无处不在,这意味着它们是细菌的可靠碳和能量来源,细菌已经开发出复杂的策略来收获它们。本综述重点介绍自然界中可以找到的各种甘露糖苷,并详细介绍了它们的结构。它强调了它们在细胞相互作用中的参与,并最终描述了有关细菌为代谢它们而开发的催化机制和代谢途径的最新发现。
更新日期:2016-12-20
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