In anti-NMDA receptor (NMDAR) encephalitis, antibody-mediated dysfunction of NMDARs causes severe neuropsychiatric symptoms, including psychosis, memory deficits, and movement disorders. However, it remains elusive how antibody-mediated NMDAR dysfunction leads to these symptoms, and whether the symptoms arise from impairment in specific brain regions and the interactions between impaired regions.

中文翻译：

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抗NMDA受体脑炎患者大规模脑网络的功能连通性：一项观察性研究。

在抗NMDA受体（NMDAR）脑炎中，抗体介导的NMDAR功能障碍会导致严重的神经精神症状，包括精神病，记忆力减退和运动障碍。但是，尚不清楚如何通过抗体介导的NMDAR功能障碍导致这些症状，以及症状是否是由于特定脑区的损伤以及受损区域之间的相互作用引起的。