In their placebo-controlled clinical trial, Fallon and colleagues compare the benefits of fluoxetine (10–80 mg per day) and cognitive behavioural therapy (CBT; 11 sessions), alone or in combination, in the management of hypochondriasis (n=195). At 24 weeks, response rates with treatment were not significantly different from placebo (proportion of responders: CBT alone 40%, fluoxetine alone 44%, joint treatment 47%, and placebo 30%). In secondary analysis, at 24 weeks the Whiteley Index score was 16% lower in the fluoxetine cohort compared with the group receiving placebo, with longitudinal analysis suggesting a more rapid reduction in symptoms with fluoxetine (p=0·043).

中文翻译：

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研究综述

在他们的安慰剂对照临床试验中，Fallon及其同事比较了氟西汀（每天10-80毫克）和认知行为疗法（CBT； 11节）在治疗软骨病（单例或联合使用）时的益处（n = 195） 。在第24周，治疗的缓解率与安慰剂没有显着差异（缓解的比例：仅CBT占40％，氟西汀单独占44％，联合治疗为47％，安慰剂为30％）。在二级分析中，与接受安慰剂的组相比，氟西汀组在24周时的Whiteley指数得分降低了16％，而纵向分析表明，氟西汀的症状减轻得更快（p = 0·043）。