Jari Tiihonen and colleagues¹ presented a retrospective cohort study on the comparative efficacy of various pharmacological treatments for unipolar depression in the prevention of hospital readmissions. The authors concluded that lithium used as monotherapy offered the lowest risk of readmission. Although this study was innovative in its evaluation of the effect of individual pharmacological drugs, we have concerns on issues of measurement and interpretability of results.¹

中文翻译：

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锂在单极抑郁症患者中的使用

Jari Tiihonen及其同事^1进行了一项回顾性队列研究，研究了各种药物治疗单相抑郁症在预防住院率方面的相对疗效。作者得出的结论是，锂作为单一疗法使用时，再次入院的风险最低。尽管这项研究在评估单个药理药物的效果方面是创新性的，但我们对测量和结果的可解释性存在关注。^1个