William McDaniel and colleagues raise an important point concerning the uncertainty about what dose of ketamine should be combined with electroconvulsive therapy (ECT) when studying its potential benefit. In our study,¹ we used a subanaesthetic dose (0·05mg/kg) that showed no benefit for either efficacy or protection of cognitive function, but we acknowledged that our data could not exclude beneficial effects from other ketamine doses or protocols.

中文翻译：

---

氯胺酮-ECT研究–作者的回复

William McDaniel及其同事在研究氯胺酮的潜在益处时，就氯胺酮应与电惊厥疗法（ECT）联合使用的剂量的不确定性提出了一个重要观点。在我们的研究中，¹我们使用了麻醉剂量（0·05mg / kg），对麻醉效果或保护认知功能均无益处，但我们承认我们的数据不能排除其他氯胺酮剂量或方案的有益作用。