Naratriptan, active pharmaceutical ingredient with antimigraine activity was electrochemically detected in untreated screen-printed carbon electrodes (SPCEs). Cyclic voltammetry and differential pulse voltammetry were used to carry out quantitative analysis of this molecule (in a Britton-Robinson buffer solution at pH 3.0) through its irreversible oxidation (diffusion controlled) at a potential of +0.75 V (vs. Ag pseudoreference electrode). Naratriptan oxidation product is an indole based dimer with a yellowish colour (maximum absorption at 320 nm) so UV–VIS spectroelectrochemistry technique was used for the very first time as an in situ characterization and quantification technique for this molecule. A reflection configuration approach allowed its measurement over the untreated carbon based electrode. Finally, time resolved Raman Spectroelectrochemistry is used as a powerful technique to carry out qualitative and quantitative analysis of Naratriptan. Electrochemically treated silver screen-printed electrodes are shown as easy to use and cost-effective SERS substrates for the analysis of Naratriptan.

在未经处理的丝网印刷碳电极（SPCE）中电化学检测了具有抗偏头痛活性的活性药物成分那拉曲普坦。循环伏安法和微分脉冲伏安法，使用在0.75伏的电位通过其不可逆的氧化（扩散控制）来进行该分子的定量分析（在pH 3.0的Britton-Robinson缓冲液）（VS。银pseudoreference电极） 。纳拉曲普坦氧化产物是一种基于吲哚的二聚体，呈淡黄色（在320 nm处具有最大吸收），因此首次将UV-VIS光谱电化学技术用于原位分子的表征和定量技术。反射配置方法允许其在未处理的碳基电极上进行测量。最后，时间分辨拉曼光谱电化学被用作对纳拉曲普坦进行定性和定量分析的有力技术。电化学处理的银丝网印刷电极显示出易于使用且经济高效的SERS底物，用于纳拉曲普坦的分析。