Airway Mucin Concentration as a Marker of Chronic Bronchitis,The New England Journal of Medicine

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Airway Mucin Concentration as a Marker of Chronic Bronchitis
The New England Journal of Medicine ( IF 96.2 ) Pub Date : 2017-09-06 , DOI: 10.1056/nejmoa1701632
Mehmet Kesimer , Amina A. Ford , Agathe Ceppe , Giorgia Radicioni , Rui Cao , C. William Davis , Claire M. Doerschuk , Neil E. Alexis , Wayne H. Anderson , Ashley G. Henderson , R. Graham Barr , Eugene R. Bleecker , Stephanie A. Christenson , Christopher B. Cooper , MeiLan K. Han , Nadia N. Hansel , Annette T. Hastie , Eric A. Hoffman , Richard E. Kanner , Fernando Martinez , Robert Paine , Prescott G. Woodruff , Wanda K. O’Neal , Richard C. Boucher

Airway mucin concentrations may quantitate a key component of the chronic bronchitis pathophysiologic cascade that produces sputum and mediates disease severity. Studies designed to explore total mucin concentrations in sputum as a diagnostic biomarker and therapeutic target for chronic bronchitis appear to be warranted. (Funded by the National Heart, Lung, and Blood Institute and others.)

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