To the Editor: Kraft et al. (June 15 issue)1 report that in the Blinded Buprenorphine or Neonatal Morphine Solution (BBORN) trial, the duration of treatment in infants with the neonatal abstinence syndrome was shorter with buprenorphine than with morphine. I am concerned that these findings do not account for the likely effects of 30% ethanol in their standard buprenorphine solution. Ethanol is a well-known facilitator of the γ-aminobutyric acid receptor, and its inclusion (one assumes to facilitate the stability of the solution) may have had an effect on the outcome of the trial. It seems to me that Kraft et . . .

中文翻译：

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丁丙诺啡用于新生儿禁欲综合征

致编辑：卡夫（Kraft）等人。（6月15日发行）1报道，在盲目的丁丙诺啡或新生儿吗啡溶液（BBORN）试验中，丁丙诺啡的新生儿禁忌综合征婴儿的治疗时间短于吗啡。我担心这些发现不能解释标准丁丙诺啡溶液中30％乙醇的可能作用。乙醇是众所周知的γ-氨基丁酸受体的促进剂，乙醇的加入（可能有助于溶液的稳定性）可能会对试验结果产生影响。在我看来，卡夫（Kraft）等人 。。