An intramolecular C(sp³)H bond functionalization adjacent to an amide nitrogen atom was successfully developed for synthesis of 2-hydroxybenzoxazinone derivatives under environment-friendly conditions. The method featured no metal catalyst, broad substrate scopes and high yields. Besides, a radical mechanism was proposed in the reaction process. Additionally, most of target compounds exhibited potent anti-proliferative activities against MCF-7 and Hela cells.

中文翻译：

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与酰胺氮原子相邻的C（sp ³）H键的分子内官能化：2-羟基-苯并恶嗪酮衍生物的无金属合成

一个分子内的C（sp ³）H键功能与酰胺氮原子相邻已成功开发了在环境友好的条件下合成2-羟基苯并恶嗪酮衍生物。该方法无金属催化剂，底物范围宽，收率高。此外，在反应过程中还提出了自由基机理。另外，大多数目标化合物对MCF-7和Hela细胞表现出有效的抗增殖活性。