Neural Stimulation: Multiplexed Optogenetic Stimulation of Neurons with Spectrum‐Selective Upconversion Nanoparticles (Adv. Healthcare Mater. 17/2017),Advanced Healthcare Materials

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Neural Stimulation: Multiplexed Optogenetic Stimulation of Neurons with Spectrum‐Selective Upconversion Nanoparticles (Adv. Healthcare Mater. 17/2017)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-06 , DOI: 10.1002/adhm.201770090
Xudong Lin _{1,

2} , Ying Wang ₁ , Xian Chen ₃ , Runhuai Yang ₁ , Zixun Wang ₁ , Jingyu Feng ₄ , Haitao Wang ₅ , King W. C. Lai ₁ , Jufang He ₄ , Feng Wang _{2,

3} , Peng Shi _{1,

2}

Affiliation

An all‐optical neural stimulation strategy is demonstrated by utilizing spectrum‐tunable NaYF4 based upconversion nanoparticles, which are used as transducers to absorb near‐infrared energy and to emit visible light for stimulating neurons expressing channelrhodopsin proteins by Feng Wang, Peng Shi, and co‐workers in article 1700446. Depending on the different dopants in the particles, the spectrum of their upconverted emission can be tuned to accommodate different opsin proteins for multiplexed and combinatorial neural stimulation, which is systematically characterized in cultured primary neurons as well as in rodent animals.

中文翻译：

神经刺激：光谱选择性上转换纳米粒子对神经元的多重光遗传学刺激（Adv。Healthcare Mater。17/2017）

通过使用基于光谱可调的基于NaYF4的上转换纳米粒子，展示了一种全光学神经刺激策略，该纳米颗粒用作吸收近红外能量并发射可见光的转换器，以刺激Wang Feng，Peng Shi等人表达通道视紫红质蛋白的神经元。文章1700446中的工作人员。根据粒子中不同的掺杂物，可以调整其上转换发射的光谱以适应不同的视蛋白，以进行多重和组合神经刺激，这在培养的原代神经元以及啮齿动物中得到了系统地表征。。

更新日期：2017-09-06

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