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Cellulose-Organic Montmorillonite Nanocomposites as Biomacromolecular Quorum-Sensing Inhibitor
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-09-06 00:00:00 , DOI: 10.1021/acs.biomac.7b01116 Deniz Demircan 1, 2 , Sedef Ilk 3 , Baozhong Zhang 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-09-06 00:00:00 , DOI: 10.1021/acs.biomac.7b01116 Deniz Demircan 1, 2 , Sedef Ilk 3 , Baozhong Zhang 1
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The aim of this study was to develop simple cellulose nanocomposites that can interfere with the quorum-sensing (QS)-regulated physiological process of bacteria, which will provide a sustainable and inexpensive solution to the serious challenges caused by bacterial infections in various products like food packaging or biomedical materials. Three cellulose nanocomposites with 1–5 w% octadecylamine-modified montmorillonite (ODA-MMT) were prepared by regeneration of cellulose from ionic liquid solutions in the presence of ODA-MMT suspension. Structural characterization of the nanocomposites showed that the ODA-MMT can be exfoliated or intercalated, depending on the load level of the nanofiller. Thermal gravimetric analysis showed that the incorporation of ODA-MMT nanofiller can improve the thermal stability of the nanocomposites compared with regenerated cellulose. Evaluation of the anti-QS effect against a pigment-producing bacteria C. violaceum CV026 by disc diffusion assay and flask incubation assay revealed that the QS-regulated violacein pigment production was significantly inhibited by the cellulose nanocomposites without interfering the bacterial vitality. Interestingly, the nanocomposite with the lowest load of ODA-MMT exhibited the most significant anti-QS effect, which may be correlated to the exfoliation of nanofillers. To our knowledge, this is the first report on the anti-QS effect of cellulose nanocomposites without the addition of any small molecular agents. Such inexpensive and nontoxic biomaterials will thus have great potential in the development of new cellulosic materials that can effectively prevent the formation of harmful biofilms.
中文翻译：
纤维素有机蒙脱土纳米复合材料作为生物大分子群体感应抑制剂
这项研究的目的是开发能够干扰群体感应（QS）调控的细菌生理过程的简单纤维素纳米复合材料，这将为各种产品（如食品）中细菌感染引起的严峻挑战提供一种可持续且廉价的解决方案包装或生物医学材料。三种具有1-5 w％十八烷基胺改性蒙脱土的纤维素纳米复合材料（ODA-MMT）通过在ODA-MMT悬浮液存在下从离子液体溶液中再生纤维素来制备。纳米复合材料的结构表征表明，取决于纳米填料的负载水平，ODA-MMT可能会脱落或嵌入。热重分析表明，与再生纤维素相比，加入ODA-MMT纳米填料可以提高纳米复合材料的热稳定性。评估针对色素产生细菌紫罗兰C.CV026的抗QS效果通过圆盘扩散试验和烧瓶温育试验显示，纤维素纳米复合材料显着抑制了QS调节的紫堇青素色素的产生，而没有干扰细菌的生命力。有趣的是，ODA-MMT含量最低的纳米复合材料表现出最显着的抗QS效应，这可能与纳米填料的剥离有关。据我们所知，这是关于纤维素纳米复合材料抗QS效果的首次报道，没有添加任何小分子试剂。因此，这种廉价且无毒的生物材料在开发能够有效防止有害生物膜形成的新型纤维素材料方面将具有巨大的潜力。
更新日期：2017-09-07
中文翻译：
纤维素有机蒙脱土纳米复合材料作为生物大分子群体感应抑制剂
这项研究的目的是开发能够干扰群体感应（QS）调控的细菌生理过程的简单纤维素纳米复合材料，这将为各种产品（如食品）中细菌感染引起的严峻挑战提供一种可持续且廉价的解决方案包装或生物医学材料。三种具有1-5 w％十八烷基胺改性蒙脱土的纤维素纳米复合材料（ODA-MMT）通过在ODA-MMT悬浮液存在下从离子液体溶液中再生纤维素来制备。纳米复合材料的结构表征表明，取决于纳米填料的负载水平，ODA-MMT可能会脱落或嵌入。热重分析表明，与再生纤维素相比，加入ODA-MMT纳米填料可以提高纳米复合材料的热稳定性。评估针对色素产生细菌紫罗兰C.CV026的抗QS效果通过圆盘扩散试验和烧瓶温育试验显示，纤维素纳米复合材料显着抑制了QS调节的紫堇青素色素的产生，而没有干扰细菌的生命力。有趣的是，ODA-MMT含量最低的纳米复合材料表现出最显着的抗QS效应，这可能与纳米填料的剥离有关。据我们所知，这是关于纤维素纳米复合材料抗QS效果的首次报道，没有添加任何小分子试剂。因此，这种廉价且无毒的生物材料在开发能够有效防止有害生物膜形成的新型纤维素材料方面将具有巨大的潜力。
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