Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold,European Journal of Organic Chemistry

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Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2017-09-06 02:30:55 , DOI: 10.1002/ejoc.201700730
Stefano D'Errico _{1,

2} , Nicola Borbone _{1,

2} , Vincenzo Piccialli ₃ , Elena Di Gennaro ₄ , Andrea Zotti ₄ , Alfredo Budillon ₄ , Carlo Vitagliano ₄ , Ilaria Piccialli ₅ , Giorgia Oliviero _{2,

6}

Affiliation

The synthesis and evaluation of the preliminary antitumor properties of a small collection of platinum complexes, in which a cisplatin-like unit is tethered to 7-deazaadenosine through linear alkyl chains (from two to six carbon atoms) installed at the purine C6 position, are described.

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