Enantio- and diastereoselective synthesis of tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic cascade process,Organic Chemistry Frontiers

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Enantio- and diastereoselective synthesis of tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic cascade process
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-08-28 00:00:00 , DOI: 10.1039/c7qo00621g
Wei-Wei Zhao _{1,

2,

3,

4,

5} , Yan-Kai Liu _{1,

2,

3,

4,

5}

Affiliation

Tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives bearing four stereogenic centers were achieved via an asymmetric organocatalytic cascade process with excellent stereoselectivity in one single operation and H₂O as the only side product. The α,β-unsaturated carboxylic acid plays two important roles in the cascade process: the Michael acceptor and acidic co-catalyst for enamine catalysis.

中文翻译：

通过不对称有机催化级联过程的对映和非对映选择性合成四氢呋喃[2,3 - b ]呋喃-2（3 H）-one衍生物和相关的氧杂环

通过一个不对称的有机催化级联过程，具有优异的立体选择性，一次操作即可获得四氢呋喃[2,3 - b ]呋喃-2（3 H）-one衍生物，该衍生物具有四个立体生成中心，并且H ₂ O是唯一的副产物。α，β-不饱和羧酸在级联过程中起两个重要作用：迈克尔受体和用于烯胺催化的酸性助催化剂。

更新日期：2017-09-06

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