The development of smart drug delivery systems to realize controlled drug release for highly specific cancer treatment has attracted tremendous attention. Herein, nanoscale coordination polymers (NCPs) constructed from hafnium ions and bis-(alkylthio) alkene (BATA), a singlet-oxygen responsive linker, are fabricated and applied as nanocarriers to realize light-controlled drug release under a rather low optical power density. In this system, NCPs synthesized through a solvothermal method are sequentially loaded with chlorin e6 (Ce6), a photosensitizer, and doxorubicin (DOX), a chemotherapeutic drug, and then coated with lipid bilayer to allow modification with polyethylene glycol (PEG) to acquire excellent colloidal stability. The singlet oxygen produced by such NCP-Ce6-DOX-PEG nanocomposite can be used not only for photodynamic therapy, but also to induce the break of BATA linker and thus the destruction of nanoparticle structures under light exposure, thereby triggering effective drug release. Notably, with efficient tumor accumulation after intravenous injection as revealed by CT imaging, those NCP-Ce6-DOX-PEG nanoparticles could be utilized for combined chemo-photodynamic therapy with great antitumor efficacy. Thus, this work presents a unique type of NCP-based drug delivery system with biodegradability, sensitive responses to light, as well as highly efficient tumor retention for effective cancer combinational treatment.

中文翻译：

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从单线态氧敏感的纳米级配位聚合物中进行光控药物释放，从而实现癌症联合治疗

为了实现针对高度特异性癌症治疗的受控药物释放，智能药物输送系统的开发引起了极大的关注。本文中，由from离子和双-（烷硫基）烯烃（BATA）（一种单线态氧响应性连接基）构成的纳米级配位聚合物（NCPs）被制成并用作纳米载体，以在相当低的光功率密度下实现光控药物的释放。 。在该系统中，将通过溶剂热法合成的NCP依次加载光敏剂二氢卟酚e6（Ce6）和化学治疗药物阿霉素（DOX），然后涂上脂质双层以允许用聚乙二醇（PEG）修饰以获得优异的胶体稳定性。这种NCP-Ce6-DOX-PEG纳米复合材料产生的单线态氧不仅可以用于光动力疗法，而且还诱导了BATA接头的断裂，从而在曝光下破坏了纳米颗粒的结构，从而触发了有效的药物释放。值得注意的是，通过CT成像显示，静脉注射后肿瘤有效积聚，这些NCP-Ce6-DOX-PEG纳米颗粒可用于化学光动力学联合治疗，具有强大的抗肿瘤功效。因此，这项工作提出了一种独特的基于NCP的药物输送系统，该系统具有可生物降解性，对光敏感的反应以及对有效的癌症联合治疗具有高效的肿瘤保留能力。这些NCP-Ce6-DOX-PEG纳米粒子可用于化学光动力学联合治疗，具有良好的抗肿瘤功效。因此，这项工作提出了一种独特的基于NCP的药物输送系统，该系统具有可生物降解性，对光敏感的反应以及对有效的癌症联合治疗具有高效的肿瘤保留能力。这些NCP-Ce6-DOX-PEG纳米颗粒可用于化学光动力学联合治疗，具有良好的抗肿瘤功效。因此，这项工作提出了一种独特的基于NCP的药物输送系统，该系统具有可生物降解性，对光敏感的反应以及对有效的癌症联合治疗具有高效的肿瘤保留能力。