It is well known that stereotactic functional neurosurgery, using ablative procedures or deep brain stimulation (DBS) is used mainly in the surgical treatment of Parkinson’s disease, essential tremor and dystonia. These are also the only established indications for functional stereotactic neurosurgery. What is less well known is that the first ever stereotactic operation was performed 70 years ago, and was for treatment of Huntington’s disease. This historical account will review the birth of human stereotactic surgery, and it’s very first applications.

中文翻译：

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亨廷顿氏病患者在70年前率先开展了立体定向神经外科手术

众所周知，采用消融手术或深部脑刺激（DBS）的立体定向功能神经外科手术主要用于帕金森氏病，原发性震颤和肌张力障碍的外科治疗。这些也是功能性立体定向神经外科手术的唯一确定适应症。鲜为人知的是，有史以来第一次立体定向手术是在70年前进行的，用于治疗亨廷顿氏病。这个历史记录将回顾人类立体定向手术的诞生，这是第一个应用。