It is well known that stereotactic functional neurosurgery, using ablative procedures or deep brain stimulation (DBS) is used mainly in the surgical treatment of Parkinson’s disease, essential tremor and dystonia. These are also the only established indications for functional stereotactic neurosurgery. What is less well known is that the first ever stereotactic operation was performed 70 years ago, and was for treatment of Huntington’s disease. This historical account will review the birth of human stereotactic surgery, and it’s very first applications.

中文翻译：

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70 年前，亨廷顿病患者开创了人体立体定向神经外科手术


众所周知，使用消融手术或深部脑刺激（DBS）的立体定向功能神经外科主要用于帕金森病、特发性震颤和肌张力障碍的手术治疗。这些也是功能性立体定向神经外科手术唯一确定的适应症。鲜为人知的是，首例立体定向手术是在 70 年前进行的，目的是治疗亨廷顿舞蹈症。这段历史记录将回顾人体立体定向手术的诞生及其最初的应用。