Background: Two randomized trials recently demonstrated that regional nodal irradiation (RNI) could reduce the risk of recurrence in early breast cancer; however, these trials were conducted in the pretrastuzumab era. Whether these results are applicable to human epidermal growth factor receptor 2 (HER2)–positive breast cancer patients treated with anti-HER2-targeted therapy is unknown.

中文翻译：

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早期HER2阳性乳腺癌的保乳手术后的区域淋巴结照射：ALTTO试验的亚分析结果

背景：最近的两项随机试验表明，区域性淋巴结照射（RNI）可以降低早期乳腺癌复发的风险。但是，这些试验是在曲妥珠单抗前期进行的。这些结果是否适用于经过抗HER2靶向治疗的人类表皮生长因子受体2（HER2）阳性乳腺癌患者。