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Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2017-03-14 , DOI: 10.1093/jnci/djw340 Caroline Bonet 1 , Flavie Luciani 1 , Jean-François Ottavi 1 , Justine Leclerc 1 , Fanélie-Marie Jouenne 1 , Marina Boncompagni 1 , Karine Bille 1 , Véronique Hofman 1 , Guillaume Bossis 1 , Gian Marco de Donatis 1 , Thomas Strub 1 , Yann Cheli 1 , Mickaël Ohanna 1 , Frédéric Luciano 1 , Sandrine Marchetti 1 , Stéphane Rocchi 1 , Marie-Christine Birling 1 , Marie-Françoise Avril 1 , Nicolas Poulalhon 1 , Thomas Luc 1 , Corine Bertolotto 1
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2017-03-14 , DOI: 10.1093/jnci/djw340 Caroline Bonet 1 , Flavie Luciani 1 , Jean-François Ottavi 1 , Justine Leclerc 1 , Fanélie-Marie Jouenne 1 , Marina Boncompagni 1 , Karine Bille 1 , Véronique Hofman 1 , Guillaume Bossis 1 , Gian Marco de Donatis 1 , Thomas Strub 1 , Yann Cheli 1 , Mickaël Ohanna 1 , Frédéric Luciano 1 , Sandrine Marchetti 1 , Stéphane Rocchi 1 , Marie-Christine Birling 1 , Marie-Françoise Avril 1 , Nicolas Poulalhon 1 , Thomas Luc 1 , Corine Bertolotto 1
Affiliation
Background:MITF encodes an oncogenic lineage-specific transcription factor in which a germline mutation (MITFE318K) was identified in human patients predisposed to both nevus formation and, among other tumor types, melanoma. The molecular mechanisms underlying the oncogenic activity of MITFE318K remained uncharacterized.
中文翻译：
解读致癌MITF E318K在衰老延迟和黑色素瘤进展中的作用
背景：MITF编码一种致癌谱系特异性转录因子，其中在易患痣形成以及黑色素瘤等其他肿瘤类型的人类患者中鉴定出种系突变（MITF E318K）。MITF E318K致癌活性的分子机制尚未阐明。
更新日期：2017-03-14
中文翻译：
解读致癌MITF E318K在衰老延迟和黑色素瘤进展中的作用
背景：MITF编码一种致癌谱系特异性转录因子，其中在易患痣形成以及黑色素瘤等其他肿瘤类型的人类患者中鉴定出种系突变（MITF E318K）。MITF E318K致癌活性的分子机制尚未阐明。
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