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Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2017-08-31 00:00:00 , DOI: 10.1038/nrrheum.2017.134 Otavio Cabral-Marques , Gabriela Riemekasten
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2017-08-31 00:00:00 , DOI: 10.1038/nrrheum.2017.134 Otavio Cabral-Marques , Gabriela Riemekasten
Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases
中文翻译:
风湿性疾病中针对G蛋白偶联受体的功能性自身抗体
风湿性疾病中针对G蛋白偶联受体的功能性自身抗体
更新日期:2017-09-12
Nature Reviews Rheumatology, Published online: 31 August 2017; doi:10.1038/nrrheum.2017.134
Autoantibodies are known to regulate the function of G protein-coupled receptors (GPCRs), but the involvement of such functional autoantibodies in autoimmune disorders is not fully understood. In this Review, the author discuss evidence showing agonistic and antagonistic effects of anti-GPCR functional autoantibodies in the pathogenesis of different rheumatic diseases.
中文翻译:
风湿性疾病中针对G蛋白偶联受体的功能性自身抗体
风湿性疾病中针对G蛋白偶联受体的功能性自身抗体
《自然评论风湿病》,在线发布:2017年8月31日;doi:10.1038 / nrrheum.2017.134
已知自身抗体可调节G蛋白偶联受体(GPCR)的功能,但这种功能性自身抗体与自身免疫性疾病的关系尚不完全清楚。在这篇综述中,作者讨论了显示抗GPCR功能性自身抗体在不同风湿性疾病发病机理中具有激动作用和拮抗作用的证据。