The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Numerous clinical studies demonstrate a beneficial relationship between high-oleic acid diets and body composition, with emerging evidence to suggest OEA may mediate this response through modulation of lipid metabolism and energy intake. OEA exposure has been shown to stimulate fatty acid uptake, lipolysis, and β-oxidation, and also promote food intake control. Future research on high-oleic acid diets and body composition is warranted to confirm these outcomes and elucidate the underlying mechanisms by which oleic acid exerts its biological effects. These findings have significant practical implications, as the oleic acid-derived OEA molecule may be a promising therapeutic agent for weight management and obesity treatment.

脂肪酸乙醇酰胺油酰乙醇酰胺（OEA）是衍生自单不饱和脂肪酸油酸的内源性脂质介体。OEA由膜甘油磷脂合成，是核转录因子过氧化物酶体增殖物激活受体α（PPAR-α）的高亲和性激动剂。通过增加OEA生物合成的底物利用率，饮食中油酸的摄入可提高人体内OEA的循环水平。大量的临床研究表明高油酸饮食与人体成分之间存在有益的关系，新的证据表明OEA可能通过调节脂质代谢和能量摄入来介导这种反应。已经证明，暴露于OEA会刺激脂肪酸摄入，脂解和β-氧化，并促进食物摄入量的控制。有必要对高油酸饮食和身体成分进行进一步研究，以证实这些结果并阐明油酸发挥其生物学作用的潜在机制。这些发现具有重大的实际意义，因为油酸衍生的OEA分子可能是体重控制和肥胖症治疗的有前途的治疗剂。