Many marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives.

许多海洋生物活性化合物具有药用和营养价值。这些生物活性化合物是使用从海洋生物资源或化学合成中基于溶剂的提取方法制备的，这些方法成本高，效率低，产率低且对环境不利。代谢工程学的最新进展在一定程度上使这些化合物的生产更加有效，这显示了满足日益增长的海洋天然生物活性化合物需求的希望。在本文中，我们综述了用于微生物生产海洋天然生物活性化合物（包括萜类化合物及其衍生物，omega-3多不饱和脂肪酸和海洋天然药物）的微生物的代谢工程学的策略和现状，并提供了一些见解。