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Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion
Trends in Molecular Medicine ( IF 12.8 ) Pub Date : 2017-07-31 , DOI: 10.1016/j.molmed.2017.07.008
Siobhan S. Pattwell , Eric C. Holland

With an unsurpassed capacity for invasion into normal brain tissue, glioblastoma multiforme is the most lethal primary brain tumor. New research suggests that altering a subset of extracellular matrix factors, including interferon regulatory factor (IRF)3 and casein kinase (CK)2, may decrease the migratory potential of these aggressive tumors.



中文翻译:

将胶质母细胞瘤置于其位置:IRF3抑制入侵

多形性胶质母细胞瘤具有无与伦比的侵入正常脑组织的能力,是最致命的原发性脑肿瘤。新的研究表明,改变细胞外基质因子的一个子集,包括干扰素调节因子(IRF)3和酪蛋白激酶(CK)2,可能会降低这些侵袭性肿瘤的迁移潜能。

更新日期:2017-07-31
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