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Dissecting Glioma Invasiveness in a 3D-Organotypic Model
Trends in Molecular Medicine ( IF 12.8 ) Pub Date : 2017-08-03 , DOI: 10.1016/j.molmed.2017.07.009 Paolo Codega , Ingo K. Mellinghoff
中文翻译:
在3D-Organotypic模型中解剖胶质瘤侵袭性
更新日期:2017-08-03
Trends in Molecular Medicine ( IF 12.8 ) Pub Date : 2017-08-03 , DOI: 10.1016/j.molmed.2017.07.009 Paolo Codega , Ingo K. Mellinghoff
Diffuse brain infiltration by tumor cells is a hallmark of glioma. Molecular mechanisms of brain invasion are poorly understood due to the difficulty to model this process in culture. A new study published in Cell Reports developed a three-dimensional organotypic model and identified interferon regulatory factor 3 (IRF3) as repressor of glioma invasion.
中文翻译:
在3D-Organotypic模型中解剖胶质瘤侵袭性
肿瘤细胞对脑的弥漫性浸润是神经胶质瘤的标志。由于难以在培养中对这一过程进行建模,因此人们对大脑入侵的分子机制了解甚少。发表在《细胞报告》上的一项新研究开发了三维器官模型,并确定了干扰素调节因子3(IRF3)作为神经胶质瘤侵袭的阻遏物。