B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that microRNAs (miRNAs) – a class of non-coding RNAs that control gene expression – are involved in the regulation of B cell development and function. We provide here an overview of the current knowledge on the role of miRNAs and their relevant targets in B cell development, B cell activation, and B cell malignant transformation.

中文翻译：

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B细胞发育和淋巴瘤发生中的miRNA。

B淋巴细胞对于针对多种病原体的有效免疫反应至关重要。血液系统恶性肿瘤的很大一部分是B细胞起源的，这表明B细胞的发育和激活需要受到严格的调控。近年来，越来越多的证据表明，microRNA（miRNA）是一类控制基因表达的非编码RNA，参与了B细胞发育和功能的调节。我们在这里提供有关miRNA及其相关靶标在B细胞发育，B细胞活化和B细胞恶性转化中作用的当前知识的概述。