Advances in public health in the past century have seen a sharp increase in human life expectancy. With these changes have come an increased prevalence of age-related pathologies and health burdens in the elderly. Patient age is the biggest risk factor for multiple chronic conditions that often occur simultaneously within a single individual. An alternative to disease-centric therapeutic approaches is that of ‘geroscience’, which aims to define molecular mechanisms that link age to overall disease risk. One such mechanism is deregulation of CREB-regulated transcriptional coactivators (CRTCs). Initially identified for their role in modulating CREB transcription, the past 5 years has seen an expansion in knowledge of new cellular regulators and roles of CRTCs beyond CREB. CRTCs have been shown to modulate organismal aging in Caenorhabditis elegans and to impact on age-related diseases in humans. We discuss CRTC deregulation as a new driver of aging that integrates the link between age and disease risk.

在过去的一个世纪中，公共卫生的进步大大提高了人们的预期寿命。随着这些变化，老年人中与年龄有关的病理和健康负担的患病率也增加了。患者年龄是经常在一个人中同时发生的多种慢性病的最大危险因素。以疾病为中心的治疗方法的另一种选择是“基因科学”，它旨在定义将年龄与总体疾病风险联系起来的分子机制。一种这样的机制是CREB调控的转录共激活因子（CRTC）的失控。最初由于其在调节CREB转录中的作用而被确定，在过去的5年中，除了CREB以外，新细胞调节剂的知识和CRTC的作用也在不断扩展。研究表明，CRCC可以调节机体中的机体衰老。秀丽隐杆线虫会影响人类与年龄有关的疾病。我们将CRTC放松管制视为衰老的新驱动力，将年龄与疾病风险之间的联系整合在一起。