Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in vertebrate and invertebrate nervous systems. Prominent family members are the neural cell adhesion molecules NCAM and L1, which were the first to be shown to be essential not only in development but also in synaptic function and as key regulators of synapse formation, synaptic activity, plasticity, and synaptic vesicle recycling at distinct developmental and activity stages. In addition to interacting with each other, adhesion molecules interact with ion channels and cytokine and neurotransmitter receptors. Mutations in their genes are linked to neurological disorders associated with abnormal development and synaptic functioning. This review presents an overview of recent studies on these molecules and their crucial impact on neurological disorders.

中文翻译：

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免疫球蛋白超家族的神经细胞粘附分子调节突触的形成、维持和功能

免疫球蛋白超家族粘附分子是脊椎动物和无脊椎动物神经系统中最丰富的蛋白质之一。突出的家族成员是神经细胞粘附分子 NCAM 和 L1，它们是第一个被证明不仅在发育中而且在突触功能中都是必不可少的，并且是突触形成、突触活动、可塑性和突触小泡循环的关键调节因子。不同的发展和活动阶段。除了彼此相互作用外，粘附分子还与离子通道、细胞因子和神经递质受体相互作用。他们的基因突变与与异常发育和突触功能相关的神经系统疾病有关。本综述概述了最近关于这些分子的研究及其对神经系统疾病的重要影响。