Age-related neurological disorders (ANDs), including neurodegenerative diseases, are multifactorial disorders with a risk that increases with aging. ANDs are generally characterized by common neuropathological conditions of the central nervous system, such as oxidative stress, neuroinflammation, and protein misfolding. Recently, efforts have been made to overcome ANDs because of the increase in age-dependent prevalence. Ginger, the rhizome of Zingiber officinale Roscoe, is a popular food spice and has a long history of use in traditional medicine for treating various disease symptoms. The structure-activity relationships of ginger phytochemicals show that ginger can be used to treat ANDs by targeting different ligand sites. This review shows that ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone, are effective for ameliorating the neurological symptoms and pathological conditions of ANDs through by modulating cell death or cell survival signaling molecules. From this review, we conclude that the active ingredients in ginger have therapeutic potential in ANDs.

与年龄相关的神经系统疾病 (AND)，包括神经退行性疾病，是一种多因素疾病，其风险随着年龄的增长而增加。 AND 通常以中枢神经系统常见的神经病理学状况为特征，例如氧化应激、神经炎症和蛋白质错误折叠。最近，由于年龄依赖性患病率的增加，人们已努力克服 AND。生姜（Zingiber officinale Roscoe）的根茎，是一种流行的食品香料，在传统医学中用于治疗各种疾病症状有着悠久的历史。生姜植物化学物质的构效关系表明，生姜可以通过靶向不同的配体位点来治疗AND。本综述表明，生姜及其成分，如 6-姜酚、6-姜烯酚、6-paradol、姜酮和脱氢姜酮，通过调节细胞死亡或细胞存活信号分子，可有效改善 AND 的神经症状和病理状况。从这篇综述中，我们得出结论，生姜中的活性成分对 AND 具有治疗潜力。