Alcoholic liver disease (ALD) is a leading cause of chronic liver disease with a wide spectrum of manifestations including simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Liver injury in ALD is caused by chronic inflammation, which has been actively investigated as a therapeutic target for the treatment of ALD for over the last four decades. In this review, we summarize a wide variety of inflammatory mediators that have been shown to contribute to the pathogenesis of ALD, and discuss the therapeutic potential of these mediators for the treatment of ALD.

中文翻译：

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靶向炎症治疗酒精性肝病

酒精性肝病（ALD）是慢性肝病的主要原因，其表现形式广泛，包括单纯性脂肪变性到脂肪性肝炎，肝硬化和肝细胞癌。ALD引起的肝损伤是由慢性炎症引起的，在过去的四十年中，慢性炎症已被积极研究作为治疗ALD的治疗靶标。在这篇综述中，我们总结了多种炎症介质，这些介质已被证明与ALD的发病有关，并讨论了这些介质对ALD的治疗潜力。