Antimicrobial peptides (AMPs) have evolved through billions of years as part of our innate immune system. These agents are produced by various cells throughout the human body and play important roles in our ability to respond to infections. In this review, we outline evidence linking AMP expression with a range of inflammatory and autoimmune human diseases. Finally, we highlight the promise of endogenous AMP induction for the treatment of disease (i.e., host-directed therapy) and briefly mention the different peptide drugs that are currently undergoing clinical trials.

中文翻译：

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抗菌肽：在人类疾病中的作用以及作为免疫疗法的潜力

作为我们先天免疫系统的一部分，抗菌肽（AMPs）已经进化了数十亿年。这些物质由整个人体的各种细胞产生，并在我们对感染的反应能力中发挥重要作用。在这篇综述中，我们概述了将AMP表达与一系列炎症和自身免疫性人类疾病联系起来的证据。最后，我们强调了内源性AMP诱导治疗疾病（即宿主定向治疗）的前景，并简要提及了目前正在临床试验中的不同肽类药物。