Hepatocellular carcinoma (HCC) is among the most prevalent human malignancies worldwide with rising incidence in industrialised countries, few therapeutic options and poor prognosis. To expand and improve therapeutic strategies, identification of drug targets involved in several liver cancer-related pathways is crucial. Virtually all signal transduction cascades cross the nuclear envelope and therefore require components of the nuclear transport system (NTS), including nuclear transport receptors (e.g. importins and exportins) and the nuclear pore complex. Accordingly, members of the NTS represent promising targets for therapeutic intervention. Selective inhibitors of nuclear export have already entered clinical trials for various malignancies. Herein, we review the current knowledge regarding alterations of the NTS and their potential for targeted therapy in HCC.

中文翻译：

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临时去除：肝细胞癌核转运系统的改变——治疗策略的新基础

肝细胞癌 (HCC) 是世界范围内最常见的人类恶性肿瘤之一，在工业化国家的发病率不断上升，治疗选择很少，预后较差。为了扩大和改进治疗策略，确定涉及几种肝癌相关途径的药物靶点至关重要。几乎所有的信号转导级联都穿过核膜，因此需要核转运系统 (NTS) 的组成部分，包括核转运受体（例如输入蛋白和输出蛋白）和核孔复合物。因此，NTS 的成员代表了治疗干预的有希望的目标。选择性核输出抑制剂已经进入各种恶性肿瘤的临床试验。在此处，