Trends in Pharmacological Sciences ( IF 13.9 ) Pub Date : 2017-08-07 , DOI: 10.1016/j.tips.2017.07.003 Mario Cazzola , Paola Rogliani , Luigino Calzetta , Davide Lauro , Clive Page , Maria Gabriella Matera
Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) often coexist. The mechanistic links between these two diseases are complex, multifactorial, and not entirely understood, but they can influence the approach to treatment. Understanding whether COPD comes first followed by T2DM or vice versa, or whether the two diseases develop simultaneously due to common underlying mechanisms, is important for the development of novel therapeutic approaches to these two important diseases. In this review, we discuss the potential links between COPD and T2DM and pharmacological approaches that might target these links.
中文翻译:
将COPD与2型糖尿病关联的靶向机制
慢性阻塞性肺疾病(COPD)和2型糖尿病(T2DM)通常并存。这两种疾病之间的机制联系是复杂的,多因素的,尚未完全了解,但它们可以影响治疗方法。了解COPD是先发生还是继之以T2DM或反之亦然,或者两种疾病是否由于共同的潜在机制而同时发生,对于开发针对这两种重要疾病的新颖治疗方法至关重要。在这篇综述中,我们讨论了COPD和T2DM之间的潜在联系以及可能针对这些联系的药理学方法。