Annual Review of Phytopathology ( IF 9.1 ) Pub Date : 2017-08-04 00:00:00 , DOI: 10.1146/annurev-phyto-080516-035559 T. Shidore 1 , L.R. Triplett 1
Toxin-antitoxin (TA) systems are gene modules that are ubiquitous in free-living prokaryotes. Diverse in structure, cellular function, and fitness roles, TA systems are defined by the presence of a toxin gene that suppresses bacterial growth and a toxin-neutralizing antitoxin gene, usually encoded in a single operon. Originally viewed as DNA maintenance modules, TA systems are now thought to function in many roles, including bacterial stress tolerance, virulence, phage defense, and biofilm formation. However, very few studies have investigated the significance of TA systems in the context of plant-microbe interactions. This review discusses the potential impact and application of TA systems in plant-associated bacteria, guided by insights gained from animal-pathogenic model systems.
中文翻译:
毒素-抗毒素系统:对植物疾病的影响
毒素-抗毒素(TA)系统是自由生活的原核生物中普遍存在的基因模块。TA系统的结构,细胞功能和适应性功能各不相同,其定义是通过抑制细菌生长的毒素基因和通常在单个操纵子中编码的中和毒素的抗毒素基因来实现的。TA系统最初被视为DNA维护模块,现在被认为可以发挥许多作用,包括细菌抗逆性,毒力,噬菌体防御和生物膜形成。然而,很少有研究调查在植物-微生物相互作用的背景下TA系统的重要性。这篇综述讨论了TA系统在植物相关细菌中的潜在影响和应用,并以从动物致病性模型系统中获得的见识为指导。