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Tongue and Taste Organ Biology and Function: Homeostasis Maintained by Hedgehog Signaling
Annual Review of Physiology ( IF 15.7 ) Pub Date : 2017-02-13 00:00:00 , DOI: 10.1146/annurev-physiol-022516-034202
Charlotte M Mistretta 1 , Archana Kumari 1
Affiliation  

The tongue is an elaborate complex of heterogeneous tissues with taste organs of diverse embryonic origins. The lingual taste organs are papillae, composed of an epithelium that includes specialized taste buds, the basal lamina, and a lamina propria core with matrix molecules, fibroblasts, nerves, and vessels. Because taste organs are dynamic in cell biology and sensory function, homeostasis requires tight regulation in specific compartments or niches. Recently, the Hedgehog (Hh) pathway has emerged as an essential regulator that maintains lingual taste papillae, taste bud and progenitor cell proliferation and differentiation, and neurophysiological function. Activating or suppressing Hh signaling, with genetic models or pharmacological agents used in cancer treatments, disrupts taste papilla and taste bud integrity and can eliminate responses from taste nerves to chemical stimuli but not to touch or temperature. Understanding Hh regulation of taste organ homeostasis contributes knowledge about the basic biology underlying taste disruptions in patients treated with Hh pathway inhibitors.

中文翻译:



舌头和味觉器官的生物学和功能:刺猬信号维持的稳态



舌头是一个复杂的异质组织复合体,具有不同胚胎起源的味觉器官。舌味器官是乳头,由上皮细胞组成,上皮细胞包括专门的味蕾、基底层和具有基质分子、成纤维细胞、神经和血管的固有层核心。由于味觉器官在细胞生物学和感觉功能中是动态的,因此体内平衡需要在特定区室或生态位中进行严格调节。最近,Hedgehog (Hh) 通路已成为维持舌味乳头、味蕾和祖细胞增殖和分化以及神经生理功能的重要调节因子。使用癌症治疗中使用的遗传模型或药物制剂激活或抑制 Hh 信号传导,会破坏味乳头和味蕾的完整性,并可以消除味觉神经对化学刺激的反应,但不能消除对触摸或温度的反应。了解 Hh 对味觉器官稳态的调节有助于了解接受 Hh 途径抑制剂治疗的患者味觉破坏的基本生物学原理。

更新日期:2017-02-13
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