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Memory Reconsolidation Interference as an Emerging Treatment for Emotional Disorders: Strengths, Limitations, Challenges, and Opportunities
Annual Review of Clinical Psychology ( IF 17.8 ) Pub Date : 2017-05-08 00:00:00 , DOI: 10.1146/annurev-clinpsy-032816-045209
Tom Beckers 1 , Merel Kindt 2
Affiliation  

Experimental research on emotional memory reconsolidation interference, or the induction of amnesia for previously established emotional memory, has a long tradition, but the potential of that research for the development of novel interventions to treat psychological disorders has been recognized only recently. Here we provide an overview of basic research and clinical studies on emotional memory reconsolidation interference. We point out specific advantages of interventions based on memory reconsolidation interference over traditional treatment for emotional disorders. We also explain how findings from basic research suggest limitations and challenges to clinical translation that may help to understand why clinical trials have met with mixed success so far and how their success can be increased. In closing, we preview new intervention approaches beyond the induction of amnesia that the phenomenon of memory reconsolidation may afford for alleviating the burden imposed by emotional memories and comment on theoretical controversies regarding the nature of memory reconsolidation.

中文翻译:


记忆再巩固干扰作为情绪障碍的新兴治疗方法:优势、局限、挑战和机遇

情绪记忆再巩固干扰的实验研究,或对先前建立的情绪记忆的失忆症的诱导,具有悠久的传统,但该研究在开发治疗心理障碍的新干预措施方面的潜力直到最近才得到认可。在这里,我们概述了情绪记忆再巩固干扰的基础研究和临床研究。我们指出了基于记忆再巩固干预的干预措施相对于情绪障碍的传统治疗的具体优势。我们还解释了基础研究的结果如何表明临床转化的局限性和挑战,这可能有助于理解为什么临床试验迄今为止取得了喜忧参半的成功,以及如何提高它们的成功率。最后,

更新日期:2017-05-08
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