OBJECTIVE Although several risk factors have been identified for alcohol use disorder, many individuals with these factors do not go on to develop the disorder. Identifying early phenotypic differences between vulnerable individuals and healthy control subjects could help identify those at higher risk. Binge drinking, defined as reaching a blood alcohol level of 80 mg%, carries a risk of negative legal and health outcomes and may be an early marker of vulnerability. Using a carefully controlled experimental paradigm, the authors tested the hypothesis that risk factors for alcohol use disorder, including family history of alcoholism, male sex, impulsivity, and low level of response to alcohol, would predict rate of binging during an individual alcohol consumption session. METHOD This cross-sectional study included 159 young social drinkers who completed a laboratory session in which they self-administered alcohol intravenously. Cox proportional hazards models were used to determine whether risk factors for alcohol use disorder were associated with the rate of achieving a binge-level exposure. RESULTS A greater percentage of relatives with alcoholism (hazard ratio: 1.04, 95% CI=1.02-1.07), male sex (hazard ratio: 1.74, 95% CI=1.03-2.93), and higher impulsivity (hazard ratio: 1.17, 95% CI=1.00 to 1.37) were associated with a higher rate of binging throughout the session. Participants with all three risk factors had the highest rate of binging throughout the session compared with the lowest risk group (hazard ratio: 5.27, 95% CI=1.81-15.30). CONCLUSIONS Binge drinking may be an early indicator of vulnerability to alcohol use disorder and should be carefully assessed as part of a thorough clinical evaluation.

中文翻译：

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酒精使用障碍和酒精消耗率的脆弱性。

目的尽管已查明酒精滥用障碍的一些危险因素，但许多具有这些因素的人并没有继续发展为该障碍。识别弱势个体与健康对照者之间的早期表型差异可以帮助识别高危人群。暴饮暴食定义为血液酒精含量达到80 mg％，可能会带来不利的法律和健康后果，并且可能是易感性的早期标志。作者使用严格控制的实验范式，验证了以下假设：酒精使用障碍的危险因素（包括酗酒的家族史，男性，冲动和对酒精的反应程度低）可以预测个体饮酒期间的饮酒速度。 。方法这项横断面研究包括159名年轻的社会饮酒者，他们完成了一次实验室课程，他们在这些课程中自行静脉内饮酒。考克斯比例风险模型用于确定饮酒障碍的危险因素是否与暴饮暴食率有关。结果酗酒的亲戚比例更高（危险比：1.04，95％CI = 1.02-1.07），男性（危险比：1.74，95％CI = 1.03-2.93），冲动性更高（危险比：1.17，95） ％CI = 1.00到1.37）与整个疗程中更高的结冰率相关。与最低风险组相比，所有这三个风险因素的参与者在整个疗程中的发烧率最高（风险比：5.27，95％CI = 1.81-15.30）。