OBJECTIVE Although several risk factors have been identified for alcohol use disorder, many individuals with these factors do not go on to develop the disorder. Identifying early phenotypic differences between vulnerable individuals and healthy control subjects could help identify those at higher risk. Binge drinking, defined as reaching a blood alcohol level of 80 mg%, carries a risk of negative legal and health outcomes and may be an early marker of vulnerability. Using a carefully controlled experimental paradigm, the authors tested the hypothesis that risk factors for alcohol use disorder, including family history of alcoholism, male sex, impulsivity, and low level of response to alcohol, would predict rate of binging during an individual alcohol consumption session. METHOD This cross-sectional study included 159 young social drinkers who completed a laboratory session in which they self-administered alcohol intravenously. Cox proportional hazards models were used to determine whether risk factors for alcohol use disorder were associated with the rate of achieving a binge-level exposure. RESULTS A greater percentage of relatives with alcoholism (hazard ratio: 1.04, 95% CI=1.02-1.07), male sex (hazard ratio: 1.74, 95% CI=1.03-2.93), and higher impulsivity (hazard ratio: 1.17, 95% CI=1.00 to 1.37) were associated with a higher rate of binging throughout the session. Participants with all three risk factors had the highest rate of binging throughout the session compared with the lowest risk group (hazard ratio: 5.27, 95% CI=1.81-15.30). CONCLUSIONS Binge drinking may be an early indicator of vulnerability to alcohol use disorder and should be carefully assessed as part of a thorough clinical evaluation.

中文翻译：

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酒精使用障碍的脆弱性和饮酒率。


目的 尽管已经确定了酒精使用障碍的几个危险因素，但许多具有这些因素的人并没有继续发展为酒精使用障碍。识别易受影响的个体和健康对照受试者之间的早期表型差异可以帮助识别那些风险较高的人。酗酒的定义是血液酒精含量达到 80 毫克%，会带来负面法律和健康后果的风险，并且可能是脆弱性的早期标志。作者使用严格控制的实验范式，检验了以下假设：酒精使用障碍的危险因素，包括酗酒家族史、男性、冲动和对酒精的低反应水平，可以预测个人饮酒期间的暴饮暴食率。方法 这项横断面研究纳入了 159 名年轻的社交饮酒者，他们完成了实验室会议，其中他们自行静脉注射酒精。 Cox 比例风险模型用于确定酒精使用障碍的危险因素是否与达到暴饮水平的暴露率相关。结果 酗酒的亲属比例较高（风险比：1.04，95% CI=1.02-1.07），男性（风险比：1.74，95% CI=1.03-2.93），冲动性较高（风险比：1.17，95） % CI=1.00 至 1.37）与整个训练期间较高的暴饮暴食率相关。与风险最低的组相比，具有所有三个风险因素的参与者在整个训练过程中的暴饮暴食率最高（风险比：5.27，95% CI=1.81-15.30）。结论 酗酒可能是易患酒精使用障碍的早期指标，应作为全面临床评估的一部分进行仔细评估。