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Extending the Scope of GTFR Glucosylation Reactions with Tosylated Substrates for Rare Sugars Synthesis
ChemBioChem ( IF 3.2 ) Pub Date : 2017-09-05 06:50:38 , DOI: 10.1002/cbic.201700320
Julian Görl 1 , Christian Possiel 1 , Christoph Sotriffer 2 , Jürgen Seibel 1
Affiliation  

In rare form: Tosylated glucose derivatives are used as acceptors of the glucansucrase R from S. oralis. The tosyl groups allow only distinct orientations of the acceptor in the active cleft (docking experiments), which results in highly regioselective glucosylated products.

中文翻译:

拓宽与甲苯磺酸底物的GTFR葡萄糖基化反应的范围,用于稀有糖的合成

在罕见的形式:甲苯磺酰化的葡萄糖衍生物用作从葡聚糖蔗糖酶的R受体口腔链球菌。甲苯磺酰基仅在活动裂隙中允许受体的不同取向(对接实验),这导致了高度区域选择性的糖基化产物。
更新日期:2017-09-05
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